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Study of Kindlins Reveals Novel Pathways for Cancer Treatment
Context:
A recent study from the SN Bose National Centre for Basic Sciences in Kolkata, explores the role of Kindlins adapter proteins, crucial for cellular signalling and mechanical homeostasis in cancer.
Key Findings of the Research:
- Researchers Focus was placed on Kindlins’ role in tumour progression, metastasis, and epithelial-mesenchymal transition (EMT).
- The research suggests that targeting Kindlins could provide new therapeutic strategies for cancer treatment.
- Kindlins are adapter proteins that connect extracellular mechanical cues to intracellular biochemical signals, playing a significant role in cellular signalling pathways.
- They interact with structural proteins, receptors, and transcription factors, influencing cell behaviour and homeostasis.
- Mutations in Kindlins, induced by carcinogens like nicotine and ultraviolet rays, can disrupt mechanical homeostasis, potentially leading to cancerous transformations.
Implications for Cancer Treatment:
- Therapeutic Potential: The study highlights Kindlins as promising targets for mechano-modulatory cancer therapeutics.
- Understanding the role of different Kindlin proteins can lead to innovative treatment strategies and improve response to therapy.
- Developing treatments targeting Kindlin dysfunction could address chemoresistance and tumour relapse challenges.
Mechanical Homeostasis:
- Mechanical homeostasis refers to the ability of cells within a tissue to establish, maintain, and restore their preferred morphological and mechanical state.
- This process is essential for the proper function of tissues and organs.
