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Study on Radiotherapy After Breast Cancer Surgery

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Study on Radiotherapy After Breast Cancer Surgery

Context:

Providing radiotherapy after surgery can prevent breast cancer from returning in the same place for up to 10 years, but this protective effect diminishes after a decade, with recurrence risk becoming similar to that in those who did not receive radiotherapy.

 

Findings of the Study:

  • After 10 years, 16% of those who had radiotherapy experienced cancer recurrence in the same location.
  • In comparison, 36% of those who did not receive radiotherapy experienced recurrence in the same location.
  • Fewer deaths from breast cancer were observed in the radiotherapy group (37% vs. 46%).
  • However, there were more deaths from other cancers in the radiotherapy group (20% vs. 11%).
  • Survival rates do not show a significant improvement with radiotherapy, highlighting that while it reduces local recurrence, it does not necessarily enhance overall survival.

 

About Radiation therapy:

  • Radiation therapy, or radiotherapy, is a type of cancer treatment in which specialists kill cancerous cells in the body by exposing them to ionising radiation, such as X-rays, gamma rays, high-energy electrons or heavy particles. 
  • Radiation therapy can be administered externally or internally.
  • Radiation therapy works by damaging cells by destroying their genetic material, which controls growth and division.
  • The aim is to treat the cancer while minimising harm to healthy cells.
  • Surgery followed by radiotherapy remains the standard care for women with early-stage breast cancer. 

 

Breast Cancer: 

  • Breast cancer occurs when breast cells mutate and become cancerous, multiplying to form tumours. 
  • It primarily affects women and people assigned female at birth (AFAB) aged 50 and older, also impact younger women. 
  • It can also impact men, people assigned male at birth (AMAB).

 

What is Molecular breast imaging (MBI):

  • It is an advanced, FDA-approved technology designed to detect breast cancer in women with dense breast tissue, where standard mammography may be less effective
  • Dense tissue and abnormal masses both appear white on mammograms, making it challenging to distinguish between them. 
  • MBI uses a special camera and a small amount of radioactive tracer to highlight differences in tissue activity, allowing for better differentiation between healthy dense tissue and breast irregularities. 
  • It is a highly accurate imaging method with a low likelihood of missing cancerous cells.

 

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