Chandipura Virus Outbreak in India

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Chandipura Virus Outbreak in India

Context:

The World Health Organization (WHO) has recently reported that the current outbreak of the Chandipura virus (CHPV) in India is the largest in two decades. 

 

More on News:

  • The outbreak has seen significant numbers of Acute Encephalitis Syndrome (AES) cases.
  • The Ministry of Health documented 245 cases of Acute Encephalitis Syndrome (AES), including 82 fatalities, resulting in a case fatality rate (CFR) of 33%.
  • In 2003, Andhra Pradesh experienced a large AES outbreak linked to CHPV, with 329 suspected cases and 183 deaths.

 

Key Highlights:

  • It causes sporadic cases and outbreaks of AES in the western, central, and southern parts of India. Notably prevalent during the monsoon season.
  • The issue affects 43 districts in India, especially in western, central, and southern regions like Gujarat. Outbreaks usually increase every four to five years during the monsoon season.
  • The National Joint Outbreak Response Team (NJORT) is assisting in public health measures and epidemiological investigations.
  • The Gujarat Biotechnology Research Centre (GBRC) is researching other potential viruses causing encephalitis and monitoring the situation closely.

 

Surveillance and Control Measures:

  • Surveillance efforts should focus on high-risk areas, especially children below 15 years of age presenting with acute onset of fever and central nervous system symptoms.
  • Laboratory diagnostic capacities are crucial for the timely collection, transport, and testing of serum and cerebrospinal fluid samples for serological and virological investigation.

About Chandipura virus (CHPV):

  • Family: Rhabdoviridae which also includes other members such as the lyssavirus that causes rabies)
  • Genus: Vesiculovirus
  • Discovery: Identified in 1965 in Maharashtra, India.
  • Transmitted by vectors such as Sandflies (phlebotomine and Sergentomyia species), mosquitoes (including Aedes aegypti) and ticks.
    • Virus transmitted through insect bites; resides in the salivary glands of vectors.
  • The CFR from CHPV infection is high (56-75%).
  • Symptoms include a sudden onset of fever, vomiting, and diarrhoea, along with neurological issues.
  • The condition can rapidly worsen, with potential death occurring within 48 hours of hospital admission.
  • Diagnosis involves early and precise testing through serological and virological investigations to confirm the infection
    • Survival can be increased with early access to care and intensive supportive care of patients as there is no specific antiviral treatment or vaccine available.
  • To prevent and control the issue, eliminate breeding sites by managing waste and sanitation, using repellents, wearing protective clothing, and using nets
    • Implement comprehensive vector control programs and environmental management, and educate the public and healthcare providers about prevention strategies and symptoms.

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