Codon Deoptimisation Technology

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Codon Deoptimisation Technology

Context:

Hyderabad-based vaccine manufacturer Indian Immunologicals Ltd (IIL) has achieved a significant milestone in the fight against COVID-19

 

More on News:

  • In collaboration with Griffith University, Australia, they have developed a needle-free intranasal booster vaccine against SARS-CoV-2
  • The live-attenuated booster utilises a cutting-edge technology known as “codon deoptimisation.”

About CoDe (Codon De-Optimisation):

  • It is a specialised tool designed to enhance virus attenuation through codon-pair de-optimisation. 
  • This technique modifies RNA or DNA sequences by altering the frequency of codon pairs (genetic determinants for amino acids) without changing the overall amino acid sequences
  • The primary goal is to reduce the efficiency of viral replication by using suboptimal codon pairs.

Key Highlights:

  • The new vaccine arrives amidst ongoing concerns about COVID-19 variants. Union Health Minister recently informed about the emergence of two new strains, KP.1 and KP.2, derived from the JN1 Omicron variant
    • These strains are highly transmissible but have not yet led to an increase in hospitalisations or severe cases.
  • As of December 2023, India has administered a total of 220.67 crore COVID-19 vaccine doses, but only 22.88 crore precautionary or booster doses have been given to eligible adults
  • A new intra-nasal booster vaccine could play a crucial role in enhancing booster dose uptake and providing an additional layer of protection against evolving COVID-19 variants.
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